An energetic model for macromolecules unraveling
نویسندگان
چکیده
We propose a simple approach, based on the minimization of the total (entropic plus unfolding) energy of a two-state system, describing the stretch-induced unfolding of macromolecules (proteins, silks, nanopolymers, DNA/RNA). The model is fully analytical and enlightens the role of the different energetic components regulating the unfolding evolution. As an explicit example of application we compare the analytical results with the titin Atomic Force Microscopy experiments showing the ability of the model to quantitatively reproduce the mechanical behavior of macromolecules unfolding.
منابع مشابه
An energetic model for macromolecules unfolding in stretching experiments.
We propose a simple approach, based on the minimization of the total (entropic plus unfolding) energy of a two-state system, to describe the unfolding of multi-domain macromolecules (proteins, silks, polysaccharides, nanopolymers). The model is fully analytical and enlightens the role of the different energetic components regulating the unfolding evolution. As an explicit example, we compare th...
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